CASP6

Across TCGA patient cohorts, CASP6 mutation is significantly associated with the RNA expression of many other genes, with 1,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP6-associated genes across cancer lineages are RNA5SP412, SNORD116-3, and CADM2-AS2. Each is linked with CASP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASP6-to-partner and partner-to-CASP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by CASP6-low versus CASP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP6→partner) and Y-score (partner→CASP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.612	+2.230	<.001	.005	3	3
CESC	SNORD116-3 →	+0.624	+5.103	<.001	.008	3	2
HNSC	CADM2-AS2 →	+0.029	+4.468	<.001	.006	3	2
CESC	S100A7P1 →	+0.129	+5.969	<.001	.002	3	1
CESC	C7orf66 →	+0.083	+5.539	<.001	.004	3	1
CESC	C1QBPP1 →	+0.048	+6.837	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,347 associations by consensus.

RNA5SP412 by CASP6 expression — UCEC

Explore this box plot interactively →