CASP6

Across TCGA cell cohorts, CASP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,271 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASP6-associated GO terms across cancer lineages are Response to staurosporine, Cellular response to staurosporine, and Positive regulation of necroptotic process. Each is linked with CASP6 in more than 17 cancer types. Because this analysis shows association rather than direction, both CASP6-to-partner and partner-to-CASP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to staurosporine grouped by CASP6-low versus CASP6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP6→partner) and Y-score (partner→CASP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to staurosporine →	+0.241	+1.368	<.001	<.001	3	18
LUNG_SCLC	Cellular response to staurosporine →	+0.241	+1.368	<.001	<.001	3	18
BLOOD_Myeloma	Positive regulation of necroptotic process →	+0.176	+1.569	.002	<.001	3	17
LUNG_SCLC	Hepatocyte apoptotic process →	+0.242	+1.557	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cellular response to alkaloid →	+0.145	+0.649	<.001	.004	3	13
BLOOD_Myeloma	Positive regulation of programmed necrotic cell death →	+0.193	+1.418	<.001	.006	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,271 associations by consensus.

Response to staurosporine by CASP6 expression — LUNG_SCLC

Explore this box plot interactively →