CASP4LP

Across TCGA patient cohorts, CASP4LP mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP4LP-associated genes across cancer lineages are Bcl-2, Caspase-8, and 4E-BP1. Each is linked with CASP4LP in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP4LP-to-partner and partner-to-CASP4LP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bcl-2 grouped by CASP4LP-low versus CASP4LP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP4LP→partner) and Y-score (partner→CASP4LP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bcl-2 →	+0.514	+2.196	.004	.034	3	1
UCEC	Caspase-8 →	-0.290	-2.973	.027	.035	3	1
UCEC	4E-BP1 →	+0.377	+3.029	.007	.018	3	1
UCEC	MEK1 →	+0.429	+3.321	.025	.010	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Bcl-2 by CASP4LP expression — UCEC

Explore this box plot interactively →