Across TCGA pan-cancer cohorts, CASP4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CASP4 data layer compared with 21 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CASP4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CASP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCS, UCEC, and SKCM are the cancer types where CASP4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.828	.013	26	view →
SKCM	DFS	Median	III,IV	0.050	0.648	<.001	6	view →
SARC	OS	Median	All	0.174	0.730	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: CASP4 tumor-vs-normal RNA expression · all CASP4 data types