Across TCGA patient cohorts, CASP4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP4-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4G. Each is linked with CASP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP4-to-partner and partner-to-CASP4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP4→partner) and Y-score (partner→CASP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.292	-2.906	.002	.001	3	1
UCEC	EGFR →	-0.210	-1.678	<.001	.023	3	1
UCEC	eIF4G →	+0.274	+2.459	.021	.019	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.321	.011	.034	3	1
UCEC	Gab2 →	+0.369	+3.459	.007	.005	3	1
UCEC	INPP4B →	-0.260	-3.459	.036	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

CASP4 survival (RNA) · tumor vs normal (RNA) · all CASP4 data types