Across TCGA cell cohorts, CASP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,272 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CASP4-associated GO terms across cancer lineages are Positive regulation of interleukin-18-mediated signaling pathway, Regulation of interleukin-18-mediated signaling pathway, and Pyroptotic inflammatory response. Each is linked with CASP4 in more than 16 cancer types. Because this analysis shows association rather than direction, both CASP4-to-partner and partner-to-CASP4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP4→partner) and Y-score (partner→CASP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of interleukin-18-mediated signaling pathway →	+1.873	+4.522	<.001	<.001	3	17
SOFT_TISSUE	Regulation of interleukin-18-mediated signaling pathway →	+1.340	+3.180	<.001	<.001	3	17
BLOOD_Myeloma	Pyroptotic inflammatory response →	+0.141	+2.407	.001	.005	3	16
LUNG_NSCLC_LUSC	Cytoplasmic pattern recognition receptor signaling pathway →	+0.092	+1.788	<.001	.007	3	15
OESOPHAGUS	Pattern recognition receptor signaling pathway →	+0.072	+2.087	<.001	.003	3	14
LUNG_SCLC	Innate immune response-activating signaling pathway →	+0.068	+2.956	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,272 associations by consensus.

Exploration

CASP4 survival (RNA) · tumor vs normal (RNA) · all CASP4 data types