CASP2

Across TCGA patient cohorts, CASP2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP2-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and Chk1. Each is linked with CASP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP2-to-partner and partner-to-CASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CASP2-low versus CASP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP2→partner) and Y-score (partner→CASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.449	+3.321	.002	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.803	+2.479	.001	.010	3	2
UCEC	Chk1 →	-0.143	-2.321	.036	.033	3	2
COAD	c-Kit →	+0.698	+2.815	.034	.036	3	1
UCEC	eIF4E →	+0.231	+3.584	.007	.002	2	2
UCEC	Myosin-IIa_pS1943 →	+0.181	+3.169	.034	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by CASP2 expression — UCEC

Explore this box plot interactively →