CASP2

Across TCGA cell cohorts, CASP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,224 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASP2-associated GO terms across cancer lineages are RNA export from nucleus, DNA integrity checkpoint signaling, and Regulation of DNA repair. Each is linked with CASP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both CASP2-to-partner and partner-to-CASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by CASP2-low versus CASP2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP2→partner) and Y-score (partner→CASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA export from nucleus →	+0.109	+0.935	.001	.003	3	16
BONE	DNA integrity checkpoint signaling →	+0.098	+1.042	<.001	<.001	3	16
BONE	Regulation of DNA repair →	+0.090	+1.201	<.001	<.001	3	15
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.055	+1.130	<.001	<.001	3	15
BONE	Chromosome condensation →	+0.183	+1.155	<.001	<.001	3	15
BONE	Replication fork processing →	+0.137	+1.074	.004	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,224 associations by consensus.

RNA export from nucleus by CASP2 expression — BONE

Explore this box plot interactively →