CASP2

Across TCGA cell cohorts, CASP2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASP2-associated genes across cancer lineages are TTLL8, OR52H1, and ELOA3DP. Each is linked with CASP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP2-to-partner and partner-to-CASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by CASP2-low versus CASP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP2→partner) and Y-score (partner→CASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.032	+3.347	<.001	.005	3	1
LARGE_INTESTINE	ELOA3DP →	+0.027	+3.688	<.001	.002	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	IL20 →	+0.168	+3.662	.004	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TTLL8 by CASP2 expression — LARGE_INTESTINE

Explore this box plot interactively →