CASP2

Across TCGA cell cohorts, CASP2 mutation is significantly associated with the mutation status of many other genes, with 2,143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASP2-associated genes across cancer lineages are WNT16, USP22, and HSP90AB1. Each is linked with CASP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CASP2-to-partner and partner-to-CASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WNT16 grouped by CASP2-low versus CASP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP2→partner) and Y-score (partner→CASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WNT16 →	+2.407	+2.886	.008	.008	1	4
BLOOD_Leukemia	USP22 →	+4.321	+5.285	.005	.005	1	3
LARGE_INTESTINE	HSP90AB1 →	+3.215	+3.415	.002	.002	1	3
LARGE_INTESTINE	AMIGO1 →	+4.799	+3.672	.002	.002	1	3
LARGE_INTESTINE	PTPN4 →	+2.407	+2.886	.008	.008	1	2
BLOOD_Leukemia	FUBP3 →	+4.736	+5.560	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,143 associations by consensus.

WNT16 by CASP2 expression — LARGE_INTESTINE

Explore this box plot interactively →