CASP14

Across TCGA patient cohorts, CASP14 protein abundance is significantly associated with the RNA expression of many other genes, with 14,930 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CASP14-associated genes across cancer lineages are CDH3, EPGN, and KIFC3. Each is linked with CASP14 in more than 3 cancer types. Because this analysis shows association rather than direction, both CASP14-to-partner and partner-to-CASP14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASP14 versus CDH3 in BRCA, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP14→partner) and Y-score (partner→CASP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDH3 →	+1.824	+0.983	<.001	.004	3	4
HNSC	EPGN →	+1.988	+1.762	<.001	<.001	3	4
OV	KIFC3 →	+1.015	+0.331	<.001	.009	2	4
PDAC	FAM83A →	+2.216	+1.736	<.001	.001	3	3
PDAC	GSDMC →	+2.026	+2.090	.001	<.001	3	3
PDAC	FAM83A-AS1 →	+2.094	+2.370	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,930 associations by consensus.

CASP14 vs CDH3 — BRCA

Explore this scatter interactively →