CASP14

Across TCGA patient cohorts, CASP14 mutation is significantly associated with the RNA expression of many other genes, with 3,025 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP14-associated genes across cancer lineages are RNA5-8SP5, ACSL6-AS1, and CBX1P5. Each is linked with CASP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP14-to-partner and partner-to-CASP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5-8SP5 grouped by CASP14-low versus CASP14-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP14→partner) and Y-score (partner→CASP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5-8SP5 →	+0.285	+5.342	<.001	.002	3	2
CESC	ACSL6-AS1 →	+0.104	+5.569	<.001	.002	3	2
CESC	CBX1P5 →	+0.078	+5.837	<.001	.001	3	2
UCEC	SOCS7 →	+0.807	+3.491	<.001	.002	3	2
UCEC	ZNF280B →	+0.699	+2.818	<.001	.001	3	2
SKCM	SYNJ2BP-COX16 →	+0.335	+2.768	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,025 associations by consensus.

RNA5-8SP5 by CASP14 expression — CESC

Explore this box plot interactively →