CASP14

Across TCGA patient cohorts, CASP14 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP14-associated genes across cancer lineages are Caveolin-1, 4E-BP1_pS65, and EGFR_pY1068. Each is linked with CASP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP14-to-partner and partner-to-CASP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by CASP14-low versus CASP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP14→partner) and Y-score (partner→CASP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caveolin-1 →	-0.737	-2.999	.029	.035	3	2
SKCM	4E-BP1_pS65 →	+0.211	+2.235	.006	.005	3	1
UCEC	EGFR_pY1068 →	-0.287	-3.169	.014	.019	3	1
UCEC	INPP4B →	-0.324	-2.321	.031	.034	3	1
UCEC	ACVRL1 →	-0.152	-2.980	.017	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-3.169	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caveolin-1 by CASP14 expression — UCEC

Explore this box plot interactively →