CASP14

Across TCGA cell cohorts, CASP14 RNA expression is significantly associated with the go_rna of many other GO terms, with 495 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CASP14-associated GO terms across cancer lineages are Purine deoxyribonucleoside metabolic process, Response to endoplasmic reticulum stress, and MDA-5 signaling pathway. Each is linked with CASP14 in more than 3 cancer types. Because this analysis shows association rather than direction, both CASP14-to-partner and partner-to-CASP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine deoxyribonucleoside metabolic process grouped by CASP14-low versus CASP14-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP14→partner) and Y-score (partner→CASP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Purine deoxyribonucleoside metabolic process →	-0.128	-2.260	.007	.002	3	4
BREAST	Response to endoplasmic reticulum stress →	+0.031	+1.431	.008	.007	3	3
BREAST	MDA-5 signaling pathway →	+0.221	+2.969	<.001	<.001	3	3
URINARY_TRACT	Aromatic amino acid transport →	-0.107	-1.992	.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	L-glutamate biosynthetic process →	+0.109	+1.021	.001	.009	3	3
BREAST	Cellular response to dsRNA →	+0.131	+3.033	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 495 associations by consensus.

Purine deoxyribonucleoside metabolic process by CASP14 expression — BREAST

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