CASP14

Across TCGA cell cohorts, CASP14 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CASP14-associated genes across cancer lineages are SPO11, ACER1, and KRTAP10-2. Each is linked with CASP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP14-to-partner and partner-to-CASP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPO11 grouped by CASP14-low versus CASP14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP14→partner) and Y-score (partner→CASP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPO11 →	+0.019	+4.969	<.001	.003	3	2
LARGE_INTESTINE	ACER1 →	+0.079	+4.145	.003	.001	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.041	+2.994	.004	.006	3	1
CNS	LRRC74A →	+0.038	+4.321	<.001	.009	3	1
CNS	GUCA1C →	+1.598	+4.169	<.001	.008	3	1
CNS	PTH2 →	+0.090	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SPO11 by CASP14 expression — BLOOD_Leukemia

Explore this box plot interactively →