Across TCGA patient cohorts, CASP12 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP12-associated genes across cancer lineages are A-Raf_pS299, FASN, and FOXO3a. Each is linked with CASP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP12-to-partner and partner-to-CASP12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP12→partner) and Y-score (partner→CASP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.116	-3.700	.018	.001	3	1
UCEC	FASN →	+0.422	+3.459	.009	.005	3	1
UCEC	FOXO3a →	-0.121	-2.308	.003	.006	3	1
UCEC	IGFBP2 →	-0.606	-3.000	.023	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.163	-2.308	.019	.006	3	1
UCEC	Rad50 →	-0.274	-1.807	.006	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

CASP12 survival (RNA) · tumor vs normal (RNA) · all CASP12 data types