CASP10

Across TCGA pan-cancer cohorts, CASP10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CASP10 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CASP10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CASP10 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where CASP10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.575	0.242	.002	23	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	16	view →
HNSC	DFS	Quartile	All	0.893	1.000	.012	7	view →
LSCC	OS	Quartile	III,IV	0.898	0.533	.033	4	view →
LUAD	OS	Quartile	All	0.927	0.602	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CASP10–PDAC (OS)

Open the PDAC breakdown →