CASP10

Across TCGA pan-cancer cohorts, CASP10 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CASP10’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CASP10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CASP10 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

CCRCC, PDAC, and COAD are the cancer types where CASP10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASP10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+0.328	<.001	9	view →
PDAC	Female	All	+0.553	<.001	8	view →
COAD	Male	II,III,IV	−0.215	.003	4	view →
LSCC	Male	II,III,IV	−0.163	.006	4	view →
HNSC	All	II,III,IV	+0.150	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CASP10–CCRCC

Open the CCRCC breakdown →