CASP10

Across TCGA patient cohorts, CASP10 mutation is significantly associated with the RNA expression of many other genes, with 2,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP10-associated genes across cancer lineages are MYO19, CYCSP17, and PDF. Each is linked with CASP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP10-to-partner and partner-to-CASP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by CASP10-low versus CASP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP10→partner) and Y-score (partner→CASP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO19 →	+0.487	+3.024	<.001	<.001	3	2
HNSC	CYCSP17 →	+0.100	+4.736	<.001	.007	3	2
SKCM	PDF →	+0.496	+2.926	<.001	<.001	3	2
SKCM	PITPNB →	+0.435	+2.713	.005	.003	3	2
UCEC	GINS3 →	+0.459	+1.684	.001	.007	3	2
SKCM	SETD3 →	+0.461	+3.932	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,668 associations by consensus.

MYO19 by CASP10 expression — UCEC

Explore this box plot interactively →