CASP10

Across TCGA patient cohorts, CASP10 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP10-associated genes across cancer lineages are Src, 14-3-3_beta, and EGFR_pY1068. Each is linked with CASP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP10-to-partner and partner-to-CASP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by CASP10-low versus CASP10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP10→partner) and Y-score (partner→CASP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src →	-0.212	-2.442	.021	.017	3	1
UCEC	14-3-3_beta →	-0.089	-1.401	.017	.046	3	1
UCEC	EGFR_pY1068 →	-0.233	-2.700	.013	.006	3	1
UCEC	eIF4E →	+0.162	+1.765	.041	.014	3	1
UCEC	ERK2 →	+0.252	+3.700	<.001	.001	3	1
UCEC	MEK1 →	+0.365	+2.169	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Src by CASP10 expression — SKCM

Explore this box plot interactively →