CASP10

Across TCGA cell cohorts, CASP10 mutation is significantly associated with the drug of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASP10-associated genes across cancer lineages are Niraparib, PCI-34051, and Vincristine. Each is linked with CASP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP10-to-partner and partner-to-CASP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by CASP10-low versus CASP10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP10→partner) and Y-score (partner→CASP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.355	+2.646	.047	.047	3	1
LARGE_INTESTINE	PCI-34051 →	+0.423	+2.646	.027	.047	3	1
LARGE_INTESTINE	Vincristine →	+0.858	+2.649	.048	.046	2	1
LARGE_INTESTINE	Uprosertib →	+0.648	+2.646	.032	.047	1	1
LARGE_INTESTINE	CDK9_5038 →	+0.657	+2.906	.016	.033	1	1
LARGE_INTESTINE	GSK2110183B →	+0.623	+2.649	.041	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Niraparib by CASP10 expression — LARGE_INTESTINE

Explore this box plot interactively →