CASP1

Across TCGA pan-cancer cohorts, CASP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CASP1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CASP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CASP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where CASP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.693	0.298	<.001	53	view →
HNSC	DFS	Quartile	III,IV	1.000	0.242	.024	15	view →
LSCC	OS	Quartile	II,III,IV	0.550	0.931	.009	8	view →
CCRCC	OS	Quartile	All	0.837	1.000	.021	5	view →
GBM	OS	Median	All	0.290	0.464	.043	2	view →
LUAD	DFS	Tertile	II,III,IV	0.712	0.221	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CASP1–PDAC (OS)

Open the PDAC breakdown →