CASP1

Across TCGA patient cohorts, CASP1 mutation is significantly associated with the RNA expression of many other genes, with 4,285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP1-associated genes across cancer lineages are RNU6-1118P, RN7SKP3, and RN7SL255P. Each is linked with CASP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP1-to-partner and partner-to-CASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1118P grouped by CASP1-low versus CASP1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP1→partner) and Y-score (partner→CASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1118P →	+0.213	+4.233	<.001	.006	3	2
SKCM	RN7SKP3 →	+0.087	+4.034	<.001	.001	3	2
BLCA	RN7SL255P →	+0.276	+3.534	.001	<.001	3	2
BLCA	RN7SL251P →	+0.129	+3.329	<.001	.006	3	2
UCEC	INO80B-WBP1 →	+0.085	+1.518	<.001	.004	3	2
SKCM	RNU1-19P →	+0.206	+3.360	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,285 associations by consensus.

RNU6-1118P by CASP1 expression — BLCA

Explore this box plot interactively →