CASP1

Across TCGA patient cohorts, CASP1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP1-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and Cyclin-B1. Each is linked with CASP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP1-to-partner and partner-to-CASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CASP1-low versus CASP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP1→partner) and Y-score (partner→CASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.299	+3.906	.002	<.001	3	2
UCEC	4E-BP1 →	+0.276	+3.906	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.786	+2.954	<.001	<.001	3	2
UCEC	eEF2 →	+0.333	+2.321	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.300	-2.584	<.001	<.001	3	1
UCEC	eIF4E →	+0.159	+2.713	.012	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

p62 Lck ligand by CASP1 expression — UCEC

Explore this box plot interactively →