CASP1

Across TCGA cell cohorts, CASP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,930 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CASP1-associated GO terms across cancer lineages are Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, Antigen processing and presentation of peptide antigen via MHC class I, and Negative regulation of viral genome replication. Each is linked with CASP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both CASP1-to-partner and partner-to-CASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of exogenous peptide antigen via MHC class Ib grouped by CASP1-low versus CASP1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP1→partner) and Y-score (partner→CASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.308	+2.880	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of peptide antigen via MHC class I →	+0.192	+2.130	.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.214	+2.145	<.001	.001	3	15
PANCREAS	Negative regulation of regulatory T cell differentiation →	+0.138	+1.893	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.104	+2.317	<.001	.001	3	15
CNS	Pyroptotic inflammatory response →	+0.142	+2.513	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,930 associations by consensus.

Antigen processing and presentation of exogenous peptide antigen via MHC class Ib by CASP1 expression — LIVER

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