CASKIN2

Across TCGA patient cohorts, CASKIN2 mutation is significantly associated with the RNA expression of many other genes, with 3,971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASKIN2-associated genes across cancer lineages are ASNSP6, UBR7, and TRIM49C. Each is linked with CASKIN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CASKIN2-to-partner and partner-to-CASKIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNSP6 grouped by CASKIN2-low versus CASKIN2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASKIN2→partner) and Y-score (partner→CASKIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	ASNSP6 →	+0.037	+5.925	.007	.002	3	4
UCEC	UBR7 →	+0.653	+2.638	<.001	<.001	3	3
READ	TRIM49C →	+0.056	+6.681	<.001	<.001	3	3
UCEC	TNKS →	+0.497	+2.606	.001	.005	3	3
SKCM	OR6C68 →	+0.015	+4.302	<.001	.007	3	2
SKCM	LINC01688 →	+0.147	+4.897	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,971 associations by consensus.

ASNSP6 by CASKIN2 expression — READ

Explore this box plot interactively →