CASKIN2

Across TCGA patient cohorts, CASKIN2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CASKIN2-associated genes across cancer lineages are HER3_pY1289, MSH6, and ER-alpha. Each is linked with CASKIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASKIN2-to-partner and partner-to-CASKIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by CASKIN2-low versus CASKIN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASKIN2→partner) and Y-score (partner→CASKIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HER3_pY1289 →	+0.188	+3.195	<.001	.010	3	2
COAD	MSH6 →	-0.721	-3.000	<.001	.035	3	2
UCEC	ER-alpha →	+0.701	+1.700	.026	.042	3	2
UCEC	ATM →	-0.453	-1.678	.009	.023	3	2
COAD	ER-alpha_pS118 →	+0.157	+3.178	.004	.010	2	2
COAD	Mre11 →	+0.224	+2.820	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

HER3_pY1289 by CASKIN2 expression — COAD

Explore this box plot interactively →