CASKIN2

Across TCGA cell cohorts, CASKIN2 mutation is significantly associated with the RNA expression of many other genes, with 215 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASKIN2-associated genes across cancer lineages are NPHS2, OR10H2, and PRR23A. Each is linked with CASKIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASKIN2-to-partner and partner-to-CASKIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by CASKIN2-low versus CASKIN2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASKIN2→partner) and Y-score (partner→CASKIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NPHS2 →	+0.150	+4.044	.001	.001	3	1
URINARY_TRACT	OR10H2 →	+0.044	+4.044	<.001	.001	3	1
URINARY_TRACT	PRR23A →	+0.022	+3.584	<.001	.005	3	1
PANCREAS	LIM2 →	+0.049	+5.614	<.001	.002	3	1
PANCREAS	KIR2DL1 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 215 associations by consensus.

NPHS2 by CASKIN2 expression — URINARY_TRACT

Explore this box plot interactively →