CASKIN1

Across TCGA patient cohorts, CASKIN1 mutation is significantly associated with the RNA expression of many other genes, with 1,647 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASKIN1-associated genes across cancer lineages are EMC7, CENPM, and TMEM11. Each is linked with CASKIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASKIN1-to-partner and partner-to-CASKIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC7 grouped by CASKIN1-low versus CASKIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASKIN1→partner) and Y-score (partner→CASKIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMC7 →	+0.309	+2.741	.007	.003	3	3
COAD	CENPM →	+0.804	+3.459	.001	.005	3	3
COAD	TMEM11 →	+0.442	+3.210	.004	.009	3	3
BRCA	MIR8070 →	+0.541	+5.250	<.001	.001	3	2
CESC	RNA5SP162 →	+0.771	+5.103	<.001	.008	3	2
CESC	RNU1-62P →	+0.238	+5.539	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,647 associations by consensus.

EMC7 by CASKIN1 expression — UCEC

Explore this box plot interactively →