CASKIN1

Across TCGA patient cohorts, CASKIN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASKIN1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK2. Each is linked with CASKIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASKIN1-to-partner and partner-to-CASKIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CASKIN1-low versus CASKIN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASKIN1→partner) and Y-score (partner→CASKIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.366	-2.987	.017	.035	3	2
UCEC	eIF4E →	+0.247	+2.584	.003	.010	3	2
UCEC	JNK2 →	+0.292	+2.415	<.001	.003	3	2
UCEC	Lck →	+0.244	+2.321	.002	.034	3	2
UCEC	AMPK_pT172 →	+0.474	+3.700	.004	.001	3	2
UCEC	ATM →	-0.377	-3.156	.038	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by CASKIN1 expression — COAD

Explore this box plot interactively →