CASKIN1

Across TCGA cell cohorts, CASKIN1 mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASKIN1-associated genes across cancer lineages are NSMCE4A, RFC5, and ASF1A. Each is linked with CASKIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASKIN1-to-partner and partner-to-CASKIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSMCE4A grouped by CASKIN1-low versus CASKIN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASKIN1→partner) and Y-score (partner→CASKIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NSMCE4A →	+0.503	+3.169	.001	.009	3	2
LARGE_INTESTINE	RFC5 →	+0.606	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ASF1A →	+0.529	+2.628	.002	.002	3	2
LARGE_INTESTINE	TRAPPC13 →	+0.412	+3.459	.006	.001	3	2
LARGE_INTESTINE	LYG1 →	+0.947	+2.628	<.001	.002	3	2
LARGE_INTESTINE	METTL14 →	+0.487	+3.169	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

NSMCE4A by CASKIN1 expression — LARGE_INTESTINE

Explore this box plot interactively →