CASK

Across TCGA patient cohorts, CASK mutation is significantly associated with the RNA expression of many other genes, with 5,261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASK-associated genes across cancer lineages are TPRKBP1, LINC02438, and TADA2B. Each is linked with CASK in more than 2 cancer types. Because this analysis shows association rather than direction, both CASK-to-partner and partner-to-CASK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPRKBP1 grouped by CASK-low versus CASK-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASK→partner) and Y-score (partner→CASK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TPRKBP1 →	+0.084	+3.450	.001	.006	3	3
UCEC	LINC02438 →	+0.607	+2.247	<.001	<.001	3	3
UCEC	TADA2B →	+0.338	+1.577	<.001	<.001	3	3
UCEC	GPR108 →	+0.334	+2.694	<.001	<.001	3	3
STAD	MIR548AZ →	+0.390	+4.090	.004	.004	3	2
UCEC	TXNL4B →	+0.481	+1.847	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,261 associations by consensus.

TPRKBP1 by CASK expression — BLCA

Explore this box plot interactively →