CASK

Across TCGA patient cohorts, CASK mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASK-associated genes across cancer lineages are MSH2, mTOR_pS2448, and PDCD4. Each is linked with CASK in more than 1 cancer types. Because this analysis shows association rather than direction, both CASK-to-partner and partner-to-CASK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by CASK-low versus CASK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASK→partner) and Y-score (partner→CASK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.205	-1.558	.002	.015	3	2
UCEC	mTOR_pS2448 →	-0.107	-1.834	.012	.007	3	2
UCEC	PDCD4 →	-0.341	-1.575	.011	.008	3	2
UCEC	14-3-3_beta →	-0.114	-2.365	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.220	-2.087	.002	.004	3	1
UCEC	eIF4E →	+0.184	+1.954	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

MSH2 by CASK expression — UCEC

Explore this box plot interactively →