CASK

Across TCGA cell cohorts, CASK mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASK-associated genes across cancer lineages are NPVF, OR10G7, and MS4A18. Each is linked with CASK in more than 1 cancer types. Because this analysis shows association rather than direction, both CASK-to-partner and partner-to-CASK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by CASK-low versus CASK-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASK→partner) and Y-score (partner→CASK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NPVF →	+0.015	+4.285	<.001	.007	3	1
STOMACH	OR10G7 →	+0.067	+4.285	<.001	.007	3	1
STOMACH	MS4A18 →	+0.012	+4.285	<.001	.007	3	1
STOMACH	DEFA3 →	+0.507	+5.247	<.001	<.001	3	1
STOMACH	CCDC179 →	+0.065	+5.247	<.001	<.001	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.615	+2.714	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

NPVF by CASK expression — STOMACH

Explore this box plot interactively →