CASD1

Across TCGA pan-cancer cohorts, CASD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CASD1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CASD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CASD1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where CASD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.566	0.928	<.001	14	view →
LSCC	DFS	Median	III,IV	0.444	1.000	.007	14	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.101	.038	6	view →
GBM	OS	Quartile	All	0.655	0.231	.039	5	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.397	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CASD1–HNSC (OS)

Open the HNSC breakdown →