CASD1

Across TCGA patient cohorts, CASD1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASD1-associated genes across cancer lineages are mTOR_pS2448, Notch1, and ASNS. Each is linked with CASD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASD1-to-partner and partner-to-CASD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CASD1-low versus CASD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASD1→partner) and Y-score (partner→CASD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.130	-1.787	.017	.026	3	2
UCEC	Notch1 →	+0.168	+1.817	.001	.015	3	2
UCEC	ASNS →	+0.486	+2.222	<.001	.010	3	2
UCEC	ATM →	-0.414	-2.000	.012	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.490	+1.604	.024	.041	3	2
UCEC	4E-BP1 →	+0.353	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

mTOR_pS2448 by CASD1 expression — UCEC

Explore this box plot interactively →