CASC8

Across TCGA pan-cancer cohorts, CASC8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CASC8 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CASC8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CASC8 expression acts as an unfavorable survival marker, although some lineages such as THCA and UCEC show a favorable association.

LUAD, ACC, and HNSC are the cancer types where CASC8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.606	0.724	<.001	132	view →
ACC	DFS	Median	All	0.255	0.613	<.001	91	view →
HNSC	OS	Median	All	0.253	0.449	<.001	82	view →
MESO	OS	Tertile	All	0.358	0.673	<.001	78	view →
PAAD	OS	Tertile	All	0.301	0.594	<.001	71	view →
SKCM	DFS	Median	All	0.657	0.832	<.001	50	view →
LIHC	OS	Quartile	III,IV	0.180	0.412	.004	31	view →
LGG	OS	Median	All	0.824	0.936	<.001	30	view →
ESCA	OS	Tertile	II,III,IV	0.595	0.841	.001	21	view →
UVM	DFS	Quartile	II,III,IV	0.488	0.790	.004	21	view →
CESC	DFS	Tertile	II,III,IV	0.652	0.865	.012	18	view →
KIRC	DFS	Median	II,III,IV	0.746	0.849	.027	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CASC8–LUAD (DFS)

Open the LUAD breakdown →