CASC23

Across TCGA pan-cancer cohorts, CASC23 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated CASC23 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher CASC23 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CASC23 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SARC show a favorable association.

ESCA, HNSC, and BLCA are the cancer types where CASC23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	All	0.371	0.534	.029	45	view →
HNSC	DFS	Tertile	All	0.809	0.291	.011	39	view →
BLCA	OS	Tertile	III,IV	0.140	0.588	<.001	36	view →
KIRC	DFS	Tertile	II,III,IV	0.253	0.544	.004	24	view →
GBM	OS	Tertile	All	0.190	0.431	.001	18	view →
CESC	DFS	Tertile	IV	0.053	0.529	<.001	18	view →
PAAD	DFS	Tertile	II,III,IV	0.100	0.469	.008	9	view →
PCPG	DFS	Tertile	All	0.826	0.925	.029	9	view →
SARC	OS	Tertile	All	0.846	0.680	.026	6	view →
UCEC	OS	Tertile	All	0.899	0.932	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

CASC23–ESCA (DFS)

Open the ESCA breakdown →