CASC22

Across TCGA pan-cancer cohorts, CASC22 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CASC22’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CASC22 RNA is repressed in tumor relative to normal tissue. In most cancer types CASC22 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where CASC22 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASC22 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.208	<.001	11	view →
KIRP	All	All	−0.404	<.001	9	view →
LIHC	All	All	+0.213	.005	6	view →
KICH	All	All	+0.652	.028	2	view →
BRCA	All	II,III,IV	+0.008	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CASC22–KIRC

Open the KIRC breakdown →