CASC2

Across TCGA patient cohorts, CASC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,675 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CASC2-associated proteins across cancer lineages are LZTFL1, TPPP3, and WDR19. Each is linked with CASC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both CASC2-to-partner and partner-to-CASC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASC2 versus LZTFL1 in BRCA, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CASC2→partner) and Y-score (partner→CASC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LZTFL1 →	+0.642	+0.476	<.001	<.001	3	7
GBM	TPPP3 →	+1.157	+0.449	<.001	<.001	3	6
BRCA	WDR19 →	+0.510	+0.516	<.001	<.001	3	6
BRCA	ARL3 →	+0.357	+0.345	<.001	<.001	3	6
BRCA	BBS1 →	+0.695	+0.465	<.001	<.001	3	6
GBM	IFT74 →	+0.462	+0.407	.002	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,675 associations by consensus.

CASC2 vs LZTFL1 — BRCA

Explore this scatter interactively →