CASC2

Across TCGA patient cohorts, CASC2 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASC2-associated genes across cancer lineages are LINC01050, MIR98, and MIR8058. Each is linked with CASC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASC2-to-partner and partner-to-CASC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01050 grouped by CASC2-low versus CASC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASC2→partner) and Y-score (partner→CASC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01050 →	+0.341	+4.064	<.001	.001	3	1
UCEC	MIR98 →	+0.389	+3.386	.001	.008	3	1
UCEC	MIR8058 →	+0.517	+3.666	.001	.004	3	1
UCEC	LINC01727 →	+0.109	+3.551	.001	.007	3	1
UCEC	CKS1BP6 →	+0.533	+3.466	.007	.008	3	1
UCEC	RN7SL134P →	+0.230	+4.014	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

LINC01050 by CASC2 expression — UCEC

Explore this box plot interactively →