Across TCGA pan-cancer cohorts, CASC17 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CASC17’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CASC17 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CASC17 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
HNSC and KIRC are the cancer types where CASC17 tumor–normal differential expression is most reproducible.