CASC16

Across TCGA pan-cancer cohorts, CASC16 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CASC16 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher CASC16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CASC16 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ACC show a favorable association.

DLBC, BLCA, and ACC are the cancer types where CASC16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	IV	0.213	0.931	.001	93	view →
BLCA	DFS	Median	II,III,IV	0.678	0.560	.002	68	view →
ACC	DFS	Median	All	0.791	0.470	.002	61	view →
KIRP	OS	Median	All	0.942	0.823	<.001	55	view →
STAD	OS	Tertile	All	0.464	0.635	.001	46	view →
PAAD	OS	Tertile	II,III,IV	0.708	0.428	.003	30	view →
ESCA	OS	Tertile	All	0.489	1.000	.002	27	view →
BRCA	DFS	Median	IV	0.700	0.323	.006	22	view →
LIHC	OS	Quartile	All	0.327	0.618	<.001	20	view →
THYM	OS	Quartile	All	0.653	0.970	.013	11	view →
UVM	OS	Tertile	III,IV	0.463	0.920	.019	7	view →
LGG	DFS	Median	All	0.350	0.536	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CASC16–DLBC (OS)

Open the DLBC breakdown →