CASC15

Across TCGA pan-cancer cohorts, CASC15 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CASC15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CASC15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CASC15 is over-expressed in tumor, although a few such as PRAD and KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where CASC15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASC15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.854	<.001	12	view →
COAD	Female	All	+0.499	<.001	9	view →
LIHC	All	II,III,IV	+0.233	<.001	8	view →
READ	All	III,IV	+0.530	.009	5	view →
LUAD	Male	All	+1.262	<.001	4	view →
BLCA	All	All	+0.848	.007	4	view →
LUSC	All	All	+0.450	<.001	4	view →
THCA	Female	All	+0.377	<.001	4	view →
STAD	Male	II,III,IV	+0.266	.001	4	view →
CHOL	All	All	+1.613	<.001	2	view →
PRAD	All	All	−0.260	<.001	2	view →
KICH	Female	II,III,IV	−0.620	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CASC15–HNSC

Open the HNSC breakdown →