CARS2

Across TCGA patient cohorts, CARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,147 significant associations in total. LGG shows the largest number of these associations.

The most reproducible CARS2-associated GO terms across cancer lineages are Depyrimidination, Base-excision repair, AP site formation, and Base-excision repair. Each is linked with CARS2 in more than 23 cancer types. Because this analysis shows association rather than direction, both CARS2-to-partner and partner-to-CARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Depyrimidination grouped by CARS2-low versus CARS2-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CARS2→partner) and Y-score (partner→CARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Depyrimidination →	+0.051	+0.481	<.001	<.001	3	23
CHOL	Base-excision repair, AP site formation →	+0.050	+0.620	.009	.004	1	24
LAML	Base-excision repair →	+0.036	+0.331	<.001	<.001	3	21
UVM	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.042	+0.341	<.001	<.001	2	20
ACC	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.048	+0.892	<.001	<.001	3	19
LAML	Obsolete histone deacetylation →	+0.035	+0.209	<.001	.008	2	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,147 associations by consensus.

Depyrimidination by CARS2 expression — PAAD

Explore this box plot interactively →