CARS2

Across TCGA patient cohorts, CARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,637 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CARS2-associated genes across cancer lineages are GRTP1, MAMDC2, and KIT. Each is linked with CARS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CARS2-to-partner and partner-to-CARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CARS2 versus GRTP1 in HNSC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARS2→partner) and Y-score (partner→CARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GRTP1 →	+0.636	+0.340	<.001	<.001	3	5
BRCA	MAMDC2 →	-1.145	-0.534	<.001	<.001	3	5
UCEC	KIT →	-1.437	-0.534	<.001	<.001	3	4
OV	AFAP1L2 →	-1.272	-0.394	<.001	<.001	3	4
UCEC	KLHL33 →	-0.419	-0.503	.001	<.001	3	4
OV	PHLDB1 →	-1.025	-0.417	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,637 associations by consensus.

CARS2 vs GRTP1 — HNSC

Explore this scatter interactively →