CARS2

Across TCGA patient cohorts, CARS2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARS2-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with CARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARS2-to-partner and partner-to-CARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CARS2-low versus CARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARS2→partner) and Y-score (partner→CARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.725	-2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.105	-3.295	.013	.009	3	1
UCEC	EGFR_pY1068 →	-0.214	-2.222	.045	.011	3	1
UCEC	eIF4E →	+0.238	+4.000	.007	<.001	2	2
UCEC	ERK2 →	+0.316	+3.321	<.001	.009	3	1
UCEC	Gab2 →	+0.382	+3.169	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by CARS2 expression — UCEC

Explore this box plot interactively →