CARNMT1

Across TCGA patient cohorts, CARNMT1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARNMT1-associated genes across cancer lineages are FASN, 4E-BP1, and EGFR_pY1068. Each is linked with CARNMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARNMT1-to-partner and partner-to-CARNMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CARNMT1-low versus CARNMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARNMT1→partner) and Y-score (partner→CARNMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.331	+1.906	.037	.016	3	2
UCEC	4E-BP1 →	+0.335	+2.415	.002	.003	3	2
UCEC	EGFR_pY1068 →	-0.398	-4.169	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.152	-3.087	.001	<.001	3	1
UCEC	FoxM1 →	+0.219	+1.906	.035	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.152	-2.212	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FASN by CARNMT1 expression — UCEC

Explore this box plot interactively →