CARMIL2

Across TCGA patient cohorts, CARMIL2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARMIL2-associated genes across cancer lineages are Cyclin-B1, INPP4B, and ATM. Each is linked with CARMIL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARMIL2-to-partner and partner-to-CARMIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CARMIL2-low versus CARMIL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARMIL2→partner) and Y-score (partner→CARMIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.766	+2.584	<.001	<.001	3	3
COAD	INPP4B →	-0.549	-3.169	.001	.018	3	2
COAD	ATM →	-0.794	-3.000	<.001	.034	3	2
COAD	Chk2 →	-0.271	-3.313	.045	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.093	-1.653	.026	.010	3	2
UCEC	mTOR_pS2448 →	-0.107	-1.565	.032	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-B1 by CARMIL2 expression — UCEC

Explore this box plot interactively →