CARMIL2

Across TCGA cell cohorts, CARMIL2 mutation is significantly associated with the RNA expression of many other genes, with 912 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARMIL2-associated genes across cancer lineages are GPR63, SBK1, and KRT77. Each is linked with CARMIL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARMIL2-to-partner and partner-to-CARMIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR63 grouped by CARMIL2-low versus CARMIL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARMIL2→partner) and Y-score (partner→CARMIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR63 →	+0.635	+3.169	.001	.006	3	3
BLOOD_Leukemia	SBK1 →	+2.303	+3.115	<.001	.009	3	2
BLOOD_Leukemia	KRT77 →	+0.036	+2.661	<.001	.005	3	2
BLOOD_Leukemia	DMRTC1 →	+0.190	+2.855	<.001	.002	3	2
BLOOD_Leukemia	ALKBH5 →	+0.598	+3.115	.004	.009	3	2
SKIN	FAM71C →	+0.015	+4.510	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 912 associations by consensus.

GPR63 by CARMIL2 expression — LARGE_INTESTINE

Explore this box plot interactively →